Bone Grafts And Substitutes Market Snapshot trends & Company Overview by 2024

15 Jan 2019 - The global Bone Grafts and Substitutes Market was valued at over USD 2.3 billion in 2015 and is anticipated to reach over USD 3.6 billion by 2024, with a CAGR of 5.2%. Global bone graft and substitute market is expected to grow rapidly due to the increase in geriatric population, changes in technologies and launch of innovative products. Furthermore, increase in number of accidents leading to fractures, weakness of bones and reimbursement policy. The other factors driving the market growth are the increase in medical awareness, taking as minimum risk as they can. Hence, leading to more patient satisfaction and decrease in mortality rate. Bone graft and substitute is bioresorbable, osteoinductive (induction of host’s stem cells for proliferation), osteogenesis (origination of new bone from live cells in host body), osteoconductive (inward movement of mesenchymal cells that are involved in formation of bones) and cost effective.

On the basis of type of technology, Bone graft and substitute market is classified into Autograft, Allograft and Bone graft substitutes. Autograft- Bone is harvested from within the host’s body. So, there is less risk of rejection as it is from the patient’s body. But, there are some complications with it as additional post-operative procedures are required in for taking out the cells or bones from the other part of the body. To overcome these issues, the allograft method is used . Allograft consists of demineralized bone matrix, freeze dried bones and fresh frozen bones. In allograft, the source is corpse and as it is easily available in different sizes and shapes and also the risk to the patient is negligible. However, there are high chances of infection, and to mitigate these risks, the sterilized method using freeze dried bones and fresh frozen bone is preferred.

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The distribution for allograft is done through regional tissue banks. Bone graft substitute includes Bone morphogeneticproteins (rh-BMP2, rhBMP7) and along with some growth factors (transforming growth factor- betaTGF, fibroblast growth factor FGF and Platelet Derived growth factor PDGF) helps in bone reconstruction, bone repair and regeneration; Synthetic Bone graft are created chemically using Hydroxyapatite, Tricalcium phosphate, Calcium sulphate, Calcium phosphate and some degradable and non-degradable polymers are also used. It is an alternative to allograft and autograft. BMP has some benefits over allograft by decreasing the risk of morbidity and disease transmission.

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Bone graft substitute is segmented on the basis of application- Spinal fusion, Long bone, Foot and ankle, Craniomaxilofacial, Joint reconstruction and Dental. Mostly, in long bones and spinal fusion, Synthetic bone graft is used while in Foot and ankle, Craniomaxilofacial, Joint reconstruction and Dental, allograft is used. The end use of Bone graft and substitutes are the doctors. For improved growth, cell therapy technique is used with bone graft. In cell therapy, soft tissue is injected for the treatment. It includes bone marrow and platelet rich plasma with bone graft. Due to this complementary use of products with bone graft, there is an increase in market share. Platelets help in releasing the growth factors and thus improving the osteoinductive mechanism of bone graft. Geographically, it is segmented in North America- U.S and Canada, Europe- U.K and Germany, Asia Pacific- China and Japan, Latin America- Brazil and Mexico, Middle East- South Africa. North America is one of the fastest growing country. Some of the reasons behind this are the growing geriatric population, increase in number of surgeries, more support by the government regarding reimbursement. According to Orthopedic Biomaterial market in U.S, around $2.5 billion sales is generated by Bone grafting. It is expected that the growth will increase to $2.8 billion by 2022. Each year, more than 2.2 million bone grafting are performed. The major key players in the market are Wright Medical Group, Baxter International, Medtronic plc, Zimmer Inc., Allosource, Stryker Corporation, Depuy Synthes, Orthofix Holding Inc., and NuvasineInc.

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Gene Expression Analysis Market Raw Material Analysis & Product Overview by 2025

11 Jan 2019 - The global Gene Expression Market is estimated to reach USD 11.3 billion by 2025. Market is also expected to grow at a decent rate over the forecast period driven by rising number of cancer patients, facilities for financial funding, decreased cost of sequencing, and high concentration on research & development. In emerging economies, the industry offers advantageous opportunities for growth with rising concentration on adoption and precision as well as personalization in medicines. However, currency devaluation in developing economies and initial capital investment of different instruments are considered as restraint as well as challenge for the industry.

The gene expression is a set of steps for a functional genetic code product occur in the synthesis, with the support of the data coded on genes. The process is prominent in multi cellular organisms as well as bacteria such as eukaryotes or prokaryotes, which ensure the creation of machinery macro molecular of their life. In context with the consumables of gene expressions, the industry is classified into DNA chips and reagents. The segment of reagent held the largest revenue share of consumables in the industry. This segment is anticipated to witness high growth influenced by increasing number of service center for sequencing, research & development with financial funding, and rising installation number of analysis instruments. The overall market can be segmented by technologies into Northern Blotting, SAGE, Micro array, DNA, NGS, and PCR. The NGS technological segment is considered to be the rapidly growing sector. However, the PCR technology held the largest revenue share over the forecast period. The rapid growth of NGS technology is influenced by rise in large scale gene expression demand, technological advancement & improvised throughput & speed, wide spectrum of applications, and in depth knowledge of sequencing DNA.

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The services offered by this industry are classified as bio informatics solutions and profiling services. Profiling services of gene expressions occupy the largest industry share. The profiling services provide essential insights in terms of personalized medicine, determining drug, and enhanced diagnosis of disease. Aforementioned factor would drive the demand for profiling services over the forecast period.

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The genetic code expression includes translation and transcription process. The translation process protein from RNA is a sequence occurs in the protein-based synthesis on coding genes data. The transcription from DNA to RNA can be described to the creation of coples RNA of DNA with the support of the RNA enzyme polymerase. The regulations of genetic code refer to its functions, renders cell control through structure, versatility & differentiation of cellular substance, and morphogenesis. The alteration in the overall process can be possible with such as modification of proteins after translation process, and splicing of RNA. The profiling primarily refers to the set of step used to measure the expression of numerous genetic codes in order to determine the functions related to cellular. This process can be helpful to determine the differences in molecular base of phenotypic and offers the target GE selection for research purpose. There are various techniques used for this analysis such as transcriptase sequencing, analysis of micro array, PCR based real time profiling, and serial analysis of GE among others.

However, reagents are the chemical substances required in the studies undertaken to identify the pattern. Traditionally available reagents kits include hybridization, Taq Man assay, sample labeling and amplification, sample preparation and isolation and other significant kits. The North America industry is estimated to hold the largest share, followed by Asia Pacific and Europe. The Asia Pacific region is estimated for the rapid growth over the forecast period. The growth in this region is influenced by increasing gene test popularity, government concern to improve healthcare with laws & regulation, and rising agriculture research activity. The vital factors influencing the growth and contribution of aforementioned region include development of databases, increasing R & D, and continuous advancement & innovation in technology across the world. Rising initial funding and investment for research in genetic by government as well as the growing awareness & popularity of gene expressions is expected to shift demand. Recently, classified systems of GE have determined a cancer subtype aggressive colon with features like mesenchymal, which ensures EMT of tumor cells. Some of the major players competing in this industry are Agllent Technologies, Bio Rad Laboratories, Thermo Fisher Scientific, Qiagen N.V., Illunia Inc., Affymetrix Inc., and other prominent players. High initial cost for instruments as well as lack of expertise & skilled technician would hinder the growth. However, with numerous advantages and rising interest for precise medicines, the growth & scope of new studies would influence the adoption of reagents.

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Drug Discovery Informatics Market Snapshot & Rising Regional Demand by 2022

7 Jan 2019 - Global Drug Discovery Informatics Market is expected to show a tremendous growth over the forecast period owing to the technological advancements in the field of data mining and analytics regarding structured and unstructured data explosions, and drug development. In addition, the increasing usage of cloud-based services is projected to fuel the growth of this industry.

The continuous advancements in software for the endowment of data visualization, data processing and analysis and data aggregation for the adoption of more automated and integrated lab systems. Thereby, fueling the growth of drug discovery informatics market. Furthermore, the lack of informational technology applications that provides critical attributes of data evaluation and assisting in data aggregation so as to make real-time decisions is presumed to influence research in this sector. The significant shift from conventional in-vitro drug development to computer aided drug designing as expensive failures of late drug development upsurges the use of in-silico models for early ADME/Toxicity screening is estimated to boost the growth of this sector. Moreover, the increasing disease burden due to growing incidence of chronic diseases such as infectious diseases, oncology, cardiovascular and diabetes is considered to be the major concerns for healthcare and government providers across the globe. On the basis of workflow, the market is segmented into discovery informatics and development informatics. Discovery informatics is further classified into lead generation informatics and identification and validation informatics assay development informatics. While development informatics is further categorized into FHD preparation, lead optimization, Phase IB/2 informatics, and Phase IA. Discovery informatics is estimated to hold the largest market share owing to the presence of a considerable number of in-silico databases and tools which support the process of lead identification and validation.

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On the other hand, development informatics is expected to witness a significant growth over the decade owing to the continuous progress in the sub-segments that include clinical trial data management software and services. The market on the basis of mode of service provision is classified into in-house and outsourced informatics. In-house informatics is projected to dominate the market owing to the presence of a large number of information technology platforms among the key players in this region. Outsourced informatics is estimated to witness the fastest growth over the coming six years owing to the rising collaborations between key players and software service provider so as to gain access to in-silicon databases and tools for the therapeutic drug discovery.

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On the basis of services, the market is segmented into sequence analysis platform, molecular modeling, docking, and clinical trial data management. The sequence analysis platform is expected to hold the largest market share owing to the high R&D investments for genomic sequencing which provides new avenues in lead identification. In addition, due to the cost effectiveness of sequencing, the adoption rate of it is increasing, thus, resulting in the growth of this market. Geographically, the key regions identified in this industry include North America, Europe, Asia Pacific, Latin America and the Middle East and Africa. North America is estimated to dominate the market owing to the high research and development expenditures in information technology. The growing adoption of innovative objects discovery standards is another factor presumed to propel the growth of this industry. Moreover, the presence of enhanced technological framework is anticipated to boost the market growth.

Asia Pacific is expected to witness the fastest growth over the forecast period owing to the continuous technological advancements in developing countries such as Japan, and China so as to promote the introduction of new drug targets for the reduction of chronic diseases.The key players in this industry are Jubilant Biosys, Boehringer Ingelheim GmBh, Certara, Selvita, Charles River Laboratories, DiscoverX, ChemAxon, and Infosys. Other prominent players are GVK Biosciences, Covance, Albany Molecular Research Inc., Novo Informatics and Collaborative Drug Discovery Inc. In April 2016, Certara, launched a SIVA (Simcyp in Vitro Analysis) toolkit 2.0 to assist drug development researchers with the analysis of complex in-vitro studies. In March 2016, DiscoverX, launched KILR assay platform for the use in cancer immunotherapy drug development.

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Biophotonics Market Segmentation, Product Outlook & Technology Overview by 2024

28 Dec 2018 - The global Biophotonics Market was valued at USD 34.29 billion in 2015 and is expected to reach USD 91.31 billion by 2024. The growth is primarily attributed to the advancements in nanotechnology, increasing the sophistication of medical devices and healthy demand for point-of-care treatment solutions.  Biophotonics involves the use of light energy to detect measure and manipulate the biological materials or activities. The growing sophistication of medical research is expected to fuel further studies in this field, thereby providing avenues for market growth. Besides research, biophotonics finds application in the biotechnology, defense, therapeutic, diagnostic and agriculture sector.

In-vitro diagnostic and medical imaging is expected to be the core application areas for biophotonics. However, the increased government support for innovative and affordable therapy may provide wider application scope and is expected to impact the market growth positively. Biophotonics is anticipated to witness high penetration in point-of-care devices, owing to the potential of minute observations which may offer targeted therapy options without causing any side effects. The advancements in the biosensors coupled with rapid applications of light therapy and microscopy are also expected to contribute towards industry growth.

Biophotonics techniques are rapidly deployed in agriculture applications for testing the crops. Microfluidics and monitoring techniques are expected to dominate the agriculture sector, owing to advancements in food surveillance and testing procedures. Genetically modified crops may also provide growth opportunities due to applications of this technology in biotechnology laboratories and research centers. Besides agriculture, the defense sector is also expected to provide growth opportunities owing to the emergence of chemical and biological warfare.

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The market is segmented, by the application into spectro molecular, surface imaging, biosensors, see-through imaging, light therapy and microscopy. The see-through imaging sector is expected to command the highest share owing to the healthy demand for non-invasive treatment and applications in brain imaging.  On the basis on end-use, the market is segmented into medical therapeutics and diagnostics, its related test components and non-medical applications. Although the medical sector accounts for the ongoing industry growth, future growth may be due to the increased use in the non-medical fields such as agriculture and defense. Environment monitoring applications may also propel the market demand over the next eight years.

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North America biophotonics market accounted for a sizeable share in 2015 owing to sound investment in R&D and the healthcare industry. Asia Pacific market is expected to witness significant growth due to rising geriatric population. Companies may eye developing countries such as Thailand and India, which are increasing their expenditure on healthcare facilities and R&D. Technological advancements in imaging techniques are poised to keep research active. Imaging solutions such as 3D volumetric mapping are emerging as the key research areas providing an upsurge in uptake. However, owing to the nascent nature of such technologies, the applications are limited. Active collaboration of computer engineers and biologists is expected to help overcome challenges, eventually leading to industry growth. Further, y the ongoing research in nanotechnology is anticipated to provide growth opportunities.

The industry supply chain includes biologists and imaging solutions providers, which may integrate research to develop new products. The industry may face fierce competition leading to utilization of biophotonic devices at home. It may incentivize companies to develop competencies either by research or merger & acquisitions. Precision Photonics’ acquisition by Idex Corporation is one such example, leading to the development of in-house manufacturing capabilities for Idex. The healthy growth potential may incentivize firms to enter the industry. However, with only a handful key player with hefty investments, there is a potential barrier to new entrants.
Key players in the sector include AdvanDx, Affymetrix, Andor, Carl Zeiss, FEI Company, Hamamatsu Photonics, Lumenis, Olympus Corporation and Zecotek Photonics. The industry exhibits significant dominance of the US-based firms Affymetrix, which is established player in the healthcare instrument sector and FEI Company, which is into microscopy and imaging solutions.

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Proteomics Market: Competitive Landscape & Company overview by 2024

26 Dec 2018 - The global Proteomics Market was valued at over USD 11.8 billion in 2015 and is estimated to grow at a CAGR of 20% over the forecast period. Proteomics is the study of proteins, particularly their structures and functions. Proteins are considered to be a major part of living organisms that play significant functions including catalyzing different biochemical reactions, transporting oxygen with help of hemoglobin which act as a messenger, and defending against infections with help of antibodies in the human body.

The global market is expected to witness a significant growth owing to high demand in protein engineering particularly in biopharma, diagnostics and drug discovery industry over the forecast period. Improved relation between cellular behavioral and genome sequence, is anticipated to be a key driving factor for market growth. High investment in research & development along with funds from government systems is estimated to surge the market growth. The improvements in mass spectrometry and expression technology in protein helps to obtain more data from nominal sample that behave as catalysts in proteomics segment. Increasing corporate and institutional investment in proteomic R&D for further studies is also anticipated to promote the market growth.

Increasing birth disorders, genetic disorders and healthcare expenditure, are estimated to be the major driving factors for the market growth. Swift Growth of pharmaceutical and biopharmaceutical market on owing to increasing prevalence of protein deficiency diseases such as marasmus is attributed is the demand for proteomics market has increased. Protein deficiency is widely spread among people who live in impoverished regions and in elderly people who lack access to proper nutritious food. Protein deficiency is also expected to affect people born with genetic disorder to produce certain nutritional proteins, and also people with these diseases cause them to lose appetite and experience muscle breakdown.

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Developing countries are expected to witness large number of cases owing to poverty and economic situation. Increased understanding of human genome and its applications in proteomics is expected to be an opportunity to the global market. Human Genomics focuses on the application of genomic approaches to improve understanding of human disease, drug discovery and variable drug reaction including proteomics and other significant diseases. Problems encountered by proteomics key players to obtain regulatory agreements for biomarkers, increasing costs of proteomic tools, coupled with lack of skilled research expertise are expected to restrain the market growth globally over the forecast period.

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Based on the instrument type the global market has been segmented into crystallography, SPR system, Protein microarray, spectroscopy, electrophoresis and chromatography. Protein microarray is expected to be the largest market. This technology is a high-throughput method which can be used to track the activities and interactions of proteins, and also to determine their function on a large scale. Its major advantage is that huge numbers of proteins can be easily tracked in parallel. The ability of mass spectrometry is to identify and to precisely compute large number of proteins from highly complex samples is expected to broadly impact on medicine and biology.

Various reagents required for the expression and analysis of proteins are immunoassay, protein fractionation reagents and microarray reagents. Services that are provided in proteomics market are maintenance services, data analysis, and analytical laboratory services, Analytical laboratory services include protein separation, sequencing services, and identification, whereas maintenance & data analysis include bioinformatics databases and tools.

Proteomics instrumentation market is anticipated to grow at a productive rate mainly due to the rising affordability and availability of the instruments and ability to deliver high sensitive solutions. Various recent innovations such as detection methods and protein labeling coupled with high amount of protein production, ability to provide molecule attachment applications and surface chemistry are anticipated to drive the market demand over the forecast period. North America is expected to be the largest market owing to high costs of instruments in this region. Available funds in research technology for proteomics developments from various organizations such as National Science Foundation (NSF) and National Institutes of Health(NIH) are also attributed as key factors for the market growth in this region.

Asia Pacific is expected to witness a significant growth over the forecast period. Existence of emerging economies such as India, China, Malaysia, Thailand and increasing government funds and per capita income is expected to drive the market growth in this region. The existence of high demand for protein engineering and R&D segments is also estimated to drive the market demand in this region.The key participants in the proteomics market include Danaher Corporation, ActiveX Biosciences Agilent Technologies., Life Technologies Corporation, Takara Bio Inc., New England Biolabs Inc., Other industry participants include Qiagen, Hybrigenics SA Ltd, Merck Millipore, Luminex Corporation, Promega Corporation, Tyrian Diagnostics.

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Next Generation Sequencing (NGS) Market: Snapshot & Research Methodology To 2025

5 Dec 2018 - The global Next Generation Sequencing Market is anticipated to reach USD 21.4 billion by 2025. NGS market is expected to show a tremendous growth on account of its wide applications in the treatment of cancer. NGS is the process of identifying accurate order of nucleotides within a RNA or a DNA molecule. Advancement of NGS has helped biological and medical discovery and research. It has helped in various applied fields which includes biotechnology, forensic research, virology and medical diagnosis. NGS has made possible sequencing of DNA of various species including the human genome.

Introduction of advanced genetic sequencing and development of advance techniques for whole genomes are the major drivers contributing to the overall market growth. Increasing incidences of cancer and infectious diseases coupled with aging population is expected to fuel the demand for these technologies. Further, the overall cost of genome sequencing is expected to reduce drastically on account of rapid development through research and innovation. High capacity genome sequencing has been contributing significantly towards the market growth.

NGS has wide applications in the field of exome and genome sequencing. They are widely used in the treatment of infectious disease and cancer. NGS has shown a key presence in pathogen analysis which has been helpful in the treatment of infectious diseases. The need for effective diagnosis for cancer and high growing usage of combinational biomarkers are other factors contributing to the growth of the market in recent years. NGS has been mostly a topic of research and development in the previous decade. At present they find applications in the field of oncology, prenatal testing, HLA testing, idiopathic diseases, and medical research. Research and development in the field of HLA and prenatal testing have provided new avenues to doctors in gaining insights during organ matching and organ rejection.

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The development in the treatment of genetic anomalies and diseases with the help of prenatal genome sequencing has been driving the NGS market. This technology has also helped the pharmaceutical companies in developing essential drugs for the treatment of cancer and infectious diseases. Growing concerns and increasing incidences of cancer is expected to be the major driving factor for the development of NGS.

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NGS in the field of organ transplant provides great opportunities over the forecast period. It is important that the characteristics of both the donors and the acceptors match for a successful transplant. NGS helps in studying the immune response to the transplanted organ. Medical tourism development in countries including the U.S, Israel, Singapore and Australia provide bright prospects for overall growth of the market.
Next generation sequencing market is segmented as target, genome, exon and resequencing. The largest share is held by target sequencing followed by genome sequencing. Development of whole genome sequencing capabilities is expected to show a significant growth over the forecast period. Whole genome technology is relatively new and is gaining popularity with the development of high throughput. This high throughput has helped in reducing complications associated with whole genome sequencing.

NGS includes sample enrichment, DNA tagging, library preparation, sample quality assurance, DNA quantification, data storage, genetic data assembly, analysis and interpretation. With the increase in volume of whole genome sequencing, next generation data analysis is expected to observe a significant growth over the forecast period.
Government regulatory bodies play a vital role in overall development and usage of these technologies. Medical device manufacturers in the U.S. are under the strict vigilance of Food and Drug Administration (FDA). In 2013, FDA approved four next generation gene sequencing devices which is expected to help physicians in taking a broader look at the patient’s genetic makeup. Two of the approved devices is expected to help in detecting DNA changes in the treatment of cystic fibrosis.
North America is expected to observe highest demand in the global industry on account of the well-developed healthcare sector and implementation of advanced research infrastructure. Similarly, Western Europe is expected to show a substantial demand over the forecast period on account of increasing emphasis by the regional government on healthcare facilities coupled with the stringent regulatory framework. Asia Pacific and the Middle East are expected to observe significant growth on account of the increasing government initiatives to establish proper healthcare infrastructure in developing economies including China, India, Japan and UAE.

The NGS market is dominated by few players with the help of proprietary platforms. The key industry players include Life Sciences (Roche), Thermo Fischer Scientific, Illumina and Pacific Biosciences. Other major players operating in the market include Partek Inc., Genomatix Software GmbH, Macrogen Inc., Life Technologies Corp, Perkin Elmer inc., Oxford Nanopore Technologies Ltd., Knome Inc, Agilent Technologies Inc., Biomatters Ltd., CLC Bio (Qiagen), Pacific Biosciences, BGI (Beijing Genomics Institute), DNASTAR Inc, GATC Biotech and Qiagen N.V.

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Orthobiologics Market Revenue Share By Application & Base Estimates - 2025

28 Nov 2018 - The global Orthobiologics Market size was valued at USD 5.0 Billion in 2015 and is anticipated to reach USD 10.2 billion by 2025, with a CAGR of 7.5%. Orthobiologics are elements which the orthopedic surgeons use to heal the wounds more quickly. They are utilized for the healing of injured muscles, ligaments, tendons, and broken bones. They are made up of substances found in the human body itself. These elements found popularity owing to factor such as faster healing, quick recovery, and a decrease in the number of hospital visits. The orthobiologics market provides a huge number of opportunities for growth to its shareholders.

The global orthobiologics market is poised for growth owing to the increased levels of geriatric population, technological advancements, changing lifestyles and problems related to the musculoskeletal system. The increasing trends of musculoskeletal procedures are seen to be the biggest driver for the market. Establishing strategic partnerships for the purpose of marketing is also expected to boost the demand for the global orthobiologics market. Several merchants are forming strategic partnerships to diversify their businesses, grow their overall market share and spread out their product offerings. These type of strategic alliances help the organizations to align their technologies with one another’s inventive medical device range.
A growth in the global orthobiologics market is projected on account of the requirement for safer, more effective and modern orthopedic biologic treatment. The rise in the number of obesity and arthritis cases also fuels the demand for orthobiologics treatment. The bone graft procedure accounted to be the largest segment in the global orthobiologics market. The shifting preference to biological implants from mechanical implants is accelerating the growth of this market. Another important trend that is estimated to enhance the growth of the market over next eight years is the increase in funds to improve orthobiologics.

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Factors such as growing advances in technology, the prevalence of a huge number of chronic and unidentified diseases, initiatives by the government and rise in life expectation may favorably impact the market growth. Along with this, the rising incidences of injuries by sports & road accidents and growing awareness among athletes are also driving the demand for the market.

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However, lack of clear reimbursement procedures and rigorous rules may create major hindrances for the orthobiologics demand in the market. The improvements in developing alternatives for pharmaceuticals, for making medical treatments more preventive than curative along with the country’s policy for decreasing the deficit in the budget is expected to negatively impact the global orthobiologics market. Furthermore, high costs for the procedure, lack of reliable clinical trial data and strict regulations for the approval of orthobiologics products may pose challenges to the market growth over the forecast period.

The global orthobiologics market has been segmented based on its applications and product types. On the basis of application, the market been classified into spinal surgery, joint replacement & reconstruction, and trauma surgery. On the basis of product types, the market has been segmented into bone graft substitutes, bone growth stimulators, and viscosupplements. The bone graft substitutes have further been segmented into demoralized bone matrix (DBM), bone morph genic proteins (BMP), bone allografts, and bone autographs. Additionally, viscosupplements has also been further segmented into single injection viscosupplements, 3-injection viscosupplements, and 5-injection viscosupplements. Over the past few years, the viscosupplements segments held the largest market share for orthobiologics on account of huge demand for knee treatment procedures. It is a very effective pain killer. Viscosupplements are intra-articular injections made of hyaluronic acid which helps in the treatment of osteoarthritis.

North America held the majority of the global orthobiologics market in the recent past. The high demand in the market was sustained by increased prevalence of arthritis and obesity in the region, rising demand for the treatment of various diseases such as osteoarthritis and spinal injuries. However, over the next eight years, Asia-Pacific is projected to witness the highest rate of growth for orthobiologics market. This growth will be majorly driven by the Indian and Chinese market on account of a huge number of untapped patient population, economical cost, and medical tourism. The major industry players operating in the global orthobiologics market include Stryker Corporation, Synthes, Inc., Biomet, Inc., DJO Global, Zimmer Holding, Inc., Medtronic, Inc., and Smith & Nephew, Bacterin International, Inc., DePuySynthes, Inc., Globus Medical, Inc., and Integra LifeSciences Corporation.

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Encryption Software Market|Value Chain Analysis & Technological overview 2024

16 Nov 2018 - By 2024 the global Encryption Software Market size is expected to reach $ 8,402.9 million, which is growing at a CAGR of more than 14% from 2016-2024. With the growth in the trends like Internet of Things (IoT) and Bring Your Own Device (BYOD), concerns about data security are on all-time high. These trends have further caused cyber-attacks, thefts, data breaches and commercial espionage which will drive the demand for protective software.

Developments in the terms of hardware and software in the fields of mobile technology and their increased penetration are further estimated to fuel the demand over the forecast period. The inclination of firms towards cloud computing, demand for sensitive data protection, high data volume requirements has led to increase in the demand of encryption software.
Verticals such as BFSI and healthcare are required to comply with stringent regulations set by authorities such as the PCI, HIPPA and DSS who have formulated data security solutions which has led to application of security solutions all over the world. Intellectual properties of enterprises and users have become prone to infringement and theft on account of increase in usage of internet and rapid digitization. These risks make companies implement the security solutions. Protection provided to the sensitive data and intellectual properties of enterprises is expected to drive the market over the next few years.
However implementation of such solutions which are fairly expensive can cause challenges in the fields of budgets. Furthermore, application of these provisions is considerably time-consuming and complex, though the kind of security and safety provided balance-out the challenges such as time-consumption.

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Due to well-established telecom and IT sector, North America consumed a major share. Generation of huge amounts of data that needs to be protected was the major reason behind this hiked consumption. Furthermore, increased usage of personal computers and the internet are expected to raise the demand of encryption software over the forecast period.

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"Cloud encryption to witness substantial growth over the forecast period"

By 2024, the segment that is expected to witness a growth at CAGR of 19% is the cloud computing segment. Data storage being major resource of information for industries such as retail, finance and banking has caused them to incline toward cloud computing. Flexibility and scalability offered by these solutions are the main reasons for the adoption of encryption software.
At the same time with the increase in adoption of cloud computing, the need to protect the data has also escalated. Additionally, the propagation of expert data analytics has caused raise in the rate of internet usage leading to increased use of cloud encryption software. The regulated standards are set owing to the increase in the rate of growing cyber-attacks and mobile-theft.

"BFSI dominated the application segment"

BFSI segment in 2015 captured considerable market share consuming over $600 million and is expected to grow at CAGR of 15 % by 2024. Sudden spike in the number of cyber-attacks and the ever changing nature of the industry has resulted into increase in demand of security of financial data that is sensitive from theft and infringements by lowering risks and maximizing returns. The growth in adoption of cloud technologies in banking sector is expected to drive the market for next few years.
Traditional data transfer techniques such as DVDs, email and other data transfer techniques are adopted by banks for transferring the data which are highly risky keeping in mind the level at which the infringers operate. Increase in demand of such software is expected due to implementation of such techniques. Furthermore, rise in dependency on the online method of banking and the need to protect the transactions will fuel the need of encryption software over the forecast period.

"Asia Pacific to experience robust growth; China exhibits growth potential"

In 2015, the Asia-Pacific region accounted for $500 million which is expected to increase due to organizations shifting to cloud storage facilities due to their incapacity to develop data storage infrastructures, which will surely increase the risks of losses of data, infringements and thefts escalating the demand. Countries like China and India have tremendous rate of development manufacturing sector as well as IT and telecom sector which will drive the market in the forecast period.

"The encryption software market fragmented in nature"

The key players in the market are firms like Microsoft Corporation, Cisco Systems, Symantec, EMC Corporation, Bloombase, Sophos, IBM Corporation, Intel Security and Trend Micro. These firms offer solutions to both large scale businesses and small & medium scale businesses at the same time focusing on the research and development of newer techniques of cryptography to provide optimum solutions to the clients.

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Flow Cytometry Market to 2025 with Top 10 Countries, Supply & Analysis

15 Nov 2018 - The global Flow Cytometry Market size was estimated at USD 3.27 billion in 2016 and is anticipated to grow at CAGR of 10.6% in coming years. Key drivers of this market include increasing incidence of chronic disorders that requires toxicity testing for cancer tests and need for quick, accurate and sensitive prognosis techniques for the validation of disease. Increasing awareness levels amongst healthcare experts and patients coupled with rising healthcare expenditures are major factors driving the growth. Furthermore, related benefits of cell-based assays including development in reagents and software employed for the study, ease-of-use and high sensitivity and reproductively are some other elements anticipated to boost the growth in coming years.

Technology Insights

Cell-based technology held the leading position in 2016. Rising demand for advance diagnosis and increasing awareness related to related advantages with cell-based analysis are the elements contributing to its leading position during the coming years. Cell-based flow cytometry involves substantial usage in variety of research fields. This analysis is applied in the discovery of drug for physiological importance of results. Furthermore, it is utilized in clinical studies involving endothelial cells in blood, hematopoietic progenitor cells, and tumor cells in peripheral blood and tumour stem cells. In addition, they are utilized in the study for target identification and disease mechanism.

Product Insights

In 2016, instrument segment was the market leader due to huge penetration combined with benefits such as user-friendliness, accurate result and cost-effective characteristic. Consumables and reagents, due to their high application in diagnosis of cancer are anticipated to account for high growth.

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Instruments having application in flow cytometry include sample preparation devices, cell analyzers and cell sorters involving platforms for cell analysis and replaceable components such as detectors, filters and lasers. The development of new innovative technologies including the multi-color flow cytometers combined with the ability to detect up to eighteen cell parameters concurrently is amongst the causes leading towards growth.

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Application Insights

This technology is used in industrial sectors, research and clinical diagnosis. Research segment held leading position in 2016 due to increasing R&D for cancer and other infectious diseases diagnosis and treatment. Flow cytometry has applications even in some other industries including plant tissue culture and food microbiology.
Clinical diagnosis is anticipated to be the fastest growing application segment by the year 2025. This growth is boosted by elements such as rising demand for cost-effective disease diagnostic tools and related advantages of these assays in disease detection.

End-use Insights

The commercial organization segment dominated the industry due to extensive applications in various verticals including plant cell culture, food microbiology and blood banks. The entry of reagents and multiplex probes for definite usage in diagnostics and discovery of drug is anticipated to benefit this vertical accompanied with development opportunities by offering the users in research and small- scale peripheral laboratories.
Hospitals are anticipated to grow at remunerative CAGR owing to rising number of diagnostic tests required by increasing prevalence of infectious and chronic diseases, beneficial and supportive reimbursement policies and rising awareness among patients.

Regional Insights

North America held leading position in 2016 owing to the availability of solicitous government initiatives for the growth of enhanced technologies pertaining to molecular diagnostics. Furthermore, presence of skilled experts and larger awareness levels are the other factors expected to drive the growth in regional market.
Asia Pacific is speculated to demonstrate lucrative growth over the forecast period due to rising solicitous government aid for the biotech industry growth. The economic development, increasing patient awareness level, persistently advancing healthcare infrastructure and presence of untapped opportunities are the factors contributing towards the fast growth in this region.

Competitive Insights

Some major players functioning in this industry include Agilent Technologies; Apogee Flow Systems Ltd.; Becton, Dickinson and Company; Beckman Coulter, Inc.; Bio-Rad Laboratories, Inc.; GE Healthcare; Luminex Corporation; Merck & Co., Inc., Miltenyi Biotec; Stratedigm, Inc.; Sysmex Corporation and Thermo Fisher Scientific.
The market is fierce in nature as major players are involved in persistent product development and alliances to help market penetration. Rising number of outsourcing service providers are anticipated to boost industry rivalry in the coming years.
Industry players are acquiring product penetration by establishing manufacturing plants in the untapped areas of developing countries. For instance, BD Life Sciences entered into collaboration with Seegene Inc. in September 2015, for the advancement of multiplex PCR reagents for BD max system in an inquest to attain more share.

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Molecular Scissors/ Genome Editing Market|Product Estimates & Trend Analysis 2025

6 Nov 2018 - The global Molecular Scissors/ Genome Editing Market size was worth USD 2,585.5 million in 2016 which is anticipated to grow at a CAGR of more than 13.5% during the forecast period. Application of technology in the therapeutic genetic editing process of infected tissue and cells eliminates damage causing mutations, which is expected to enlarge the market size.

The existence of robust pipeline products is anticipated to influence progress in genomics sector over the projected period. Innovative products support the DNA targeting advances with simplicity of AAV packaging for distribution, specificity of the nuclease, and improved flexibility.
Furthermore, genome editing is an upcoming stream and biotech & pharmaceutical companies are collaborating for the enhancement of technology. Several companies are also involved in product manufacturing either on their own or by the asset of strategic partners.
However, factors such as IP disputes in context with CRISPR technology and off-target toxicity issues are anticipated to restrain sector growth.

Technology Insights

Several technologies such as TALENs/MegaTALs, ZFN, and CRISPR are the latest technologies which are applicable in the genome editing field. Other methods such as Jump-In, Flp-In, PiggyBac, and antisense are applicable for genome engineering.
The largest portion was accounted by CRISPR and is anticipated to rule the industry over the forecast period. Upcoming advancements in this segment is expected to support in the projected growth in the coming years.

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Delivery Method Insights

The largest share was accounted by the ex-vivo procedure as DNA modification can be controlled easily by this method of delivery. Additionally, the duration and strength of nuclease expression can be controlled to abate off-targeting excision and maximize efficacy.
CAR-t tool which is applicable in the treatment of blood cancer as ex-vivo product is highlighted in the pipeline of therapeutic molecular scissors. Moreover, several diseases need an in-vivo method of treatment since some particular cells cannot be eliminated from the body.

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Application Insights

The largest market share was accounted by gene therapy and stem cell therapy and is expected to maintain its dominance in the coming years. Application of innovative technology for the development of novel molecules that can eradicate infectious diseases and hematological malignancies are anticipated to promote the approval of this technology over the forecast period.

End-use Insights

The largest share was attributed by biotechnology organizations as an enormous amount of research is undergoing for development of innovative therapeutics by virtue of molecular scissors.
The fastest growth is accounted by government and academic research institutes in the coming years as the adoption rate is increasing for genome engineering technology. Moreover, improvement in genome engineering techniques is expected to quicken its application in research schemes by the government.

Service Insights

Key market players offer partial services and user-friendly sets to the stem cell scientists which assist them to perform the engineering process without compromising the required pluripotency conditions.
Companies, such as Sigma-Aldrich Corporation and Thermo Fisher offer customized products for cutting the cell lines at specific points, thereby boosting the growth contract based genome editing field.

Regional Insights

The market was dominated by North America owing to rising adoption of innovative and improved technologies in the U.S. Moreover, higher occurrence rate of monogenic disorders is also accountable for the estimated share.
For instance, cystic fibrosis befalls at an occurrence of 1 in 2,500 deliveries in the U.S thereby resulting in lung and other organ damage. Furthermore, recently 1,22,000 individuals necessitate organ transplant which is gradually growing and anticipated to boost growth in the coming years. Asia Pacific is anticipated to witness substantial progress over the forecast period due to rising research in personalized medicine in this sector.

Competitive Insights

Key market entities include Thermo Fisher Scientific Inc., Sigma-Aldrich Corporation, Editas Medicine, Sangamo, Intellia Therapeutics Inc., CRISPR THERAPEUTICS and Caribou Biosciences Inc. Some companies are taking benefit of authorizations from universities for the DNA editing tools application.
These participants are involved in various approaches such as cross-linking agreements, acquisitions, and in-house research which permit the novel intellectual property licensing of innovative proteins.

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Cell Isolation/Separation Market Drivers Analysis, Overview And Outlook To 2025

22 Oct 2018 - The Global Cell Isolation/ Separation Market size was estimated at USD 3.6 billion in 2016. There has been a recent increase in the use of the cell isolation in the stem cells research and cancer studies by the biotechnology companies and pharmaceuticals. This has triggered immense demand for related products. The cell separation is used for advanced analytical procedures in cancer and stem cells research. This has resulted in high demand for proteins and in turn is expected to support the cell isolation market during the forecast period.

Personalized medicine is customized medical treatment for each individual which facilitates greater outcomes. The cell isolation market procedures can be used for personalized medicine for the early detection of the diseases and to provide proper treatment. The separation of different cell types is a vital step for research, diagnostics, biomedical, and biotechnological applications. Thus, the rising demand for personalized medicine is a major factor augmenting the cell separation products.
Product Insights
The product segment is fragmented into consumables and instruments. The consumables segment is estimated to account for the largest market share. The increase in investment in research and development activities by the biotech companies has led to a boost in the cell separation products. This has led to a surge in demand of the cell separation consumables adding to the segment growth.
The instruments segment is projected grow at a significant rate due to product development and advancement during the forecast period.
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This advancement is helpful in the efficient cell separation and diagnostics purposes. The increasing incidence of diseases is responsible for the rise in demand for therapeutics which in turn is adds to the growth of the separation products.
Type Insights
The wide use of the stem cells in various applications like biopharmaceuticals and other research is a major factor for the growth of the cell separation market. Moreover, the rise in R&D procedure for new product development and clinical trials also add to the cell isolation market share. The animal type is expected to show a fair amount of growth in the forecast period.
The growing government focus on the development of the newer drug discovery along with investments from pharmaceuticals has attributed to the growth of the cell separation market. The drug discovery and research require animal cells for the examination of the preliminary toxicity and efficacy of the new molecule. Thus, the increasing government rigidness regarding animal cells and tissue availability are expected to hinder the market growth.
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Technique Insights
There are different techniques including centrifugation, surface maker, and filtration that are used for cell isolation. The centrifugation segment is expected to hold largest market share in 2016. The rise in the application of cell isolation in the research laboratories, biotech institutes, biopharmaceutical companies and cell banks is accelerating the sector growth during the forecast period.
The filtration and surface marker segment is expected to show significant growth rate during the study period. Product development and rising investment in pharmaceutical manufacturing has led to increased share of the segment. The advanced filtration systems are used for research and production by the manufacturers for assuring the better quality of end product.
Application Insights
The biomolecule segment is reported to have the highest revenue share in 2016. The increasing focus on the production of the biopharmaceuticals such as monoclonal antibodies, biosimilars, and proteins add to the segment growth. Moreover, the increasing research investments and government funding has propelled the sector growth.
The cancer and stem cells research segment are expected to exhibit rapid growth in the forecast period. The growing investments made by the pharmaceutical companies in stem cells research is a major factor responsible for the growth of the segment. Investments are expected to yield newer products in the research process, ultimately increasing the demand for the novel and efficient techniques used in stem cells research adding to the market growth.
End User Insights
The end users segment is further categorized into research laboratories, institutes, and biotechnology & biopharmaceutical companies. The research laboratories and institutes segment accounted for the largest market share in 2016. This is due to the increased prevalence of the stem cells and cancer research.
The biopharmaceutical & biotechnology companies segment accounted for remarkable revenue share in the market. This is due to an increase in the R&D investment by biologics manufacturers for research activities related to protein therapeutics, monoclonal antibody, and cancer & stem cells research, which is expected to boost the demand for cell isolation products.
Regional Insights
North America accounted for the largest market share in the 2016. Presence of major biotechnology companies and pharmaceutical companies in the region as well as highly developed infrastructure has contributed to the growth of the regional sector. In addition, product advancements and drug discoveries in the region is further anticipated to boost growth.
Several biotechnology and pharmaceutical companies are penetrating the Asia Pacific region owing to high target population base, increasing disposable incomes, cheap labor, and rapidly growing economy. With highly populated countries, offer a large gene pool for more research thus. further helping the cell isolation market in the region. Moreover, there are less stringent regulations along with the availability of the skilled but cheap worker which add to the market growth.
Competitive Insights
Some of the key players in the market are BD Biosciences; Thermo Fisher Scientific, Inc.; Merck KGaA; Beckman Coulter, Inc.; GE Healthcare; STEMCELL Technologies Inc.; Terumo BCT; and Bio-Rad Laboratories, Inc. The increasing merger, acquisition, and collaboration between the companies have profited the cell isolation market growth. For instance, In August 2016, STEMCELL Technologies Inc. and GE Healthcare announced a licensing agreement. According to which STEMCELL Technologies’ T-Cell reagents will be commercialize by GE Healthcare. This reagent can be used for the separation, culture, and activation of T-cells in clinical applications. Moreover, the newer product launch and regional expansion have also attributed to the market growth.
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Mycoplasma Testing Market Variables, Trends & Scope by 2014-2025

1 Oct 2018 - The Global Mycoplasma Testing Market was valued at USD 446.9 million in 2016 and is anticipated to witness a lucrative growth over the forecast period. Rising number of pharmaceutical and biopharmaceutical companies, increasing R&D investment, and growing number of drug launches are major attributes that are fuelling the market.

Increase in the number of biopharmaceutical and pharmaceutical companies has been seen in the past years. This growth has been attributed by the need for advanced drugs and therapies for the treatment of chronic diseases like cancer, diabetes, cardiovascular diseases and osteoporosis among others. The research work is supported by the government by funding the pharmaceutical and biotechnology companies in order to facilitate research based activities for the development of new drugs. This may foster the growth of mycoplasma testing market.

Rising investment in R&D by dominant players has further resulted in growth of the market. In the year 2016, North America spent 28.4% of its GDP on research and development according to Global R&D Funding Forecast. This signifies significant rise in the spending by various companies for the invention of new and enhanced testing devices and kits. With the growing expenditure by the government in the healthcare industry and awareness campaigns have led to the growth of the mycoplasma testing market. Mycoplasma testing is conducted so as to ensure the product is contamination free during each stage of manufacturing process.

Mycoplasma contamination is a major cause of concern in research and development activities. Infections caused by M. orale or M. fermentans are strains that frequently are seen in humans are a key source of contamination in laboratory settings. These contaminations in cell cultures cause morphological changes, altered cell metabolism and chromosomal aberrations causing contamination in the entire cell line.

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Contamination may also result in serious complications such as pneumonia, genital infections and other respiratory disorders is also seen. Thus, to prevent such contaminations, mycoplasma testing is vital.

Product Insights

Based on the products, the market is segmented into kits, reagents, instruments, and services. Kits & reagents segment holds the largest market share owing to its repetitive purchase. Kits & reagents segment has been studied after further sub-segmentation into- nucleic acid detection kits, elimination kits, PCR assays, stains, and standards & controls.

Instruments segment is projected to show a lucrative growth in the forecast period owing to introduction of advanced automated machines for detection of mycoplasma contamination. The results obtained are fast and highly efficient.

Technology Insights

On the basis of technology, PCR segment held the largest share in 2016. PCR helps to detect the mycoplasma using its double stranded DNA. The DNA of the mycoplasma are amplified, and then a dye is used which attaches to the DNA and emits light. This shows the presence of mycoplasma.

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Microbial culture is expected to show lucrative growth over the forecast period. The increasing number of research activities in academics, research laboratories, pharmaceutical and biopharmaceutical companies is supporting the growth.

Application Insights

On the basis of application, cell line testing held the largest share in 2016. Cell line testing is generally conducted in the laboratory and is the major source of mycoplasma contamination. This segment is expected to show growth over the forecast period due to increasing application of mycoplasma testing to avoid contamination in the cell culture.

End of production cells is projected to show lucrative growth over the forecast period due to the increase in clinical trials for drug discovery and development. The quality control taken in the drug discovery is majorly contributing to the of this segment share.

End-use Insights

On the basis of end use, pharmaceutical and biotechnology companies contributed towards the largest share in 2016. The government’s support along with the huge investment made by these companies in the R&D activities has led to the development new drugs which in turn has contributed to the growth of the market.

Contract research organisations are projected to show attractive growth over the forecast period because large number of research activities is conducted by these organisations which are outsourced by the pharmaceutical and biotechnology companies.

Regional Insights

North America dominated the market in 2016 owing to the rising healthcare expenditure made by the US government in R&D activities for the development of new drugs. There is also spending on healthcare infrastructure which contributes to the growth.

Asia Pacific region is projected to show a lucrative growth over the forecast period owing to increasing awareness and funding initiatives undertaken by the government for the development of new drugs.

Competitive Insights

Some of the major key players of the market include Charles River Laboratories International, Inc.; Merck KGaA; Lonza Group Ltd.; Thermo Fisher Scientific; PromoCell GmbH; ATCC (American Type Culture Collection); Biological Industries Israel Beit Haemek Ltd.; Bionique Testing Laboratories, Inc.; and InvivoGen.

The leading manufacturers provide an extensive range of advanced testing products through their strong distribution channels across wide geographical locations. The significant strategies causing the growth of these companies include new product development, geographical expansions, and mergers & acquisitions. For example, in November 2015, Merck acquired Sigma-Aldrich Co., one of the major in the industry.

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Biopreservation Market Raw material and Technological overview 2014-2022

The Global Biopreservation Market size was estimated at $2.61 billion in 2014 and is anticipated to grow at a CAGR of 17.3% during the forecast period. Rapid growth can be attributed to the rise in healthcare expenditure which is expected to boost the market in the forecast period. Moreover, increasing R&D activities by various companies as well as research organizations funded by government initiatives in the form of grant, contacts and various other funding mechanisms have led to development of novel and innovative bio-preservation services, leading to augment the revenue growth. Growing use of bio-preservation are also supported by the rising participation of government or non-government bodies for the development of this field. For example, due to the support of the institutional and government repositories, the storage of bio-specimen has evolved to next level of advanced information from basics of patient’s phenotype, extending to genetics as well as “omics” such as proteomic information.

Product Insights

The key segments included laboratory information management systems (LIMS), media and equipment. In 2014, the equipment segment dominated the market which includes liquid nitrogen, consumables, refrigerators and freezers, having a revenue share of more than 80%. The larger share can be attributed to the high demands pertaining to bio-banks and the extensive use and importance of the aforementioned products in bio-preservation. Media segment which includes home brewed and pre-formulated media is projected to witness a healthy growth as a consequence of the increased demands of tissues, cells and other materials in bio banking and advanced products in regenerative medicines. Furthermore, the high share and preference of home brewed media in terms of bio-storage can be attributed to its cost-efficiency and effectiveness in comparison to pre-formulated media.

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Application Insights

The major application analyzed in the study comprised of drug discovery, bio-banking and regenerative medicines. Moreover, the further segmentation of bio-banking includes veterinary IVF, human sperm and human eggs. Bio-banking segment held the largest share of 72.5% in 2014. Rising awareness related to preservation of stem cells, use of assisted technology for reproduction in animals and increasing number of sperm and egg banks are anticipated to drive the growth. Additionally, the expected rise in the revenue share of the segment can be attributed to advent of new techniques used for preservation of cells for a longer span of time. Regenerative medicine is considered to be the fastest growing segment owing to the high demand pertaining to efficient and specialized techniques for bio-storage. Moreover, huge amount of investments by non-government or government organizations in the field of regenerative cell therapy research is projected to boost the growth of the overall market.

Cell providers Insights

The segment of cell providers can be analyzed on basis of tumor cells, hESC, iPSC, MSC, CD19+, and CD34+. The largest market share was held by tumor cells in terms of volume in 2014 as a consequence of their wide array of application in treatment, diagnosis and R&D of the most prevalent forms of cancer. However, the fastest growing segment is predicted to be the iPSC segment throughout the forecast period because of their promising application in regenerative medicines owing to their high propagating capacity.

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Regional Insights

Key market in 2014 was the North American having a revenue share of more than 45% owing to the innovative drug developments and therapies pertaining to the biomedical research. Also, continuous rise in the population base with chronic and acute disorders requiring treatment and diagnosis in the region is further drive the revenue generation. Asia Pacific region is expected to show a considerable growth rate over the forecast period owing to the rise in population base suffering from life threatening disorders. Moreover, increasing investments by government in R&D is leading to an urgent need for bio-storage, therefore providing a boost to the regional market.

Market Share Insights

The key players holding a significant share of the biopreservation market include Qiagen, Thermo Fisher Scientific Inc, Panasonic Biomedical, Atlanta Biologicals, LabVantage Solutions Inc., Chart MVE Biomedical, BioLife Solutions Inc., Biomatrica and BioCision. The strategic initiatives by the company including acquisitions, mergers and new product launches are done to maintain and gain a competitive edge. For instance, ATCC and BioCision in May 2013 entered in an agreement to distribute and develop line of CoolProducts having a wide array of applications in wielding procedures and biomaterials storage.

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Biochip Market Product Estimates & Trend Analysis by 2013-2024

Global Biochips Market size was valued at USD 7.63 billion in 2015. With potential applications of genomics and proteomics in biotech R&D, along with rapid technological innovation and increase in adoption of personalized medicines, it is expected that this market will witness considerable growth in revenue over the forecast period.

For biochip technology, in order to enhance its usability, there is an improvement in resolution, preparation procedures and accuracy along with the reduction in the cost of the materials associated with manufacturing the biochips. These factors are expected to further reinforce growth potential. Anticipated commercialization and launch of novel treatments and diagnosis products including non-laboratory and laboratory research is expected to fuel growth over the forecast period.

Current developments aiming to miniaturize biochips even further can be anticipated to increase the additional usage and applicability for genetic sequencing methodologies, such as diabetes genomics. With the rise in usage of the biochip technology, it is anticipated that cost of genome profiling can reduce even further for studies such as protein expression analysis among others. Hence, proteomics and genomics labeling techniques along with other protein profiling techniques are expected to witness a growth in demand.

Product Type Insights

DNA chips accounted for the largest share of revenue owing to the presence of a considerable number of applications. Cancer treatment/diagnostics has been observed to have major share for the usage of biochips. Other segments contributing for the applications of biochips include genotyping, agricultural biotechnology, genomic studies, and single nucleotide polymorphism and gene expression.

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Biochip technology has the ability for miniaturizing chemical & biological assays and molecular biology which provides a ground for in-depth R&D of molecular biology at a minute level. Furthermore, the ability of miniaturization is expected to improve even more and enhance the efficiency in terms of inputs and cost requirements.

End-use Insights

Lab-on-a-chip, cell and tissue array, protein chips and DNA chips find applications in biotechnology & pharmaceutical companies, research & academic institutes, hospitals & diagnostics and point of care settings which involves end users. Protein biochips and LOACs have found widespread use for single nucleotide polymorphism genotyping, gene expression, in vitro diagnosis, expression profiling, drug discovery, high throughput screening and tissue arrays. The commercialization of the products in the development pipelines of key market participants is also key towards the potential to drive the growth for the market.

Sophisticated robotic tools are needed for scanning and handling samples which are in micro-scale. Furthermore, for efficient data analysis efficient bioinformatics system is required. Therefore, this will increase the need for specific techniques and system which is expected to increase the demand for biochips used in sophisticated machines. This will consequently increase the price of the biochips and widen the offered product range in the market.

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Regional Insights

North-America accounted for the largest revenue share owing to the presence of government policies motivating personalized care for the patients and availability of proteomics and genetic profiling infrastructure across the country, especially in the U.S. There has also been a rise in the usage of NGS (Next Generation Sequencing) for molecular treatment and clinical diagnosis coupled with microfluidic techniques that add to the large market share.

The Asia Pacific region is expected to grow at the fastest rate during the forecasted period. Reasons contributing towards the fastest growth in the market are – increase spending by the government in order to improve healthcare and R&D infrastructure in the areas of proteomics, genomics and NGS (next generation sequencing). There has also been growing awareness in the growth market for early and effective diagnosis which will further increase the growth in the market.

Competitive Insights

Key players in the development & commercialization of biochips include PerkinElmer, Inc.; Abbott Laboratories; Bio-Rad Laboratories, Inc.; Fluidigm Corporation; Sigma-Aldrich Corporation; Agilent Technologies, Inc.; Thermo Fisher Scientific, Inc. and GE Healthcare. In order to establish themselves in the untapped market, companies are following various strategies including mergers & acquisitions, collaboration, vertical and horizontal integration in regions/countries where they can see potential growth.

For example, PerkinElmer has successfully taken over Vanadis diagnostics which undergoes cell free DNA-based noninvasive prenatal testing (NIPT) on the digital platform. This has extended PerkinElmer’s portfolio. Similar strategies by other companies is expected to influence the market positively which will also bring competitiveness in the market.

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Carcinoembryonic Antigen (CEA) Market Revenue Share By Application, 2014 & 2022

The Global Carcinoembryonic Antigen (CEA) Market is expected to reach USD 2.56 Billion by 2022, which is anticipated to grow at a CAGR of more than 6.6% during the forecast period. The market is expected to witness significant growth in the coming few years owing to various key attributes such as growing incidence of cancer and technological advancement regarding the development of novel biomarkers. According to WHO estimates in 2015, globally cancer is the second leading cause of death with over 8.8 million deaths. On the basis of the Age-Standardized rate of incidence, there are approximately 205 new cases of cancer for every 100,000 men and nearly 165 new cases of cancer for every 100,000 females in the world. Carcinoembryonic antigens are the most cost effective technique for the preclinical detection of illness.

Technological advancements pertaining to proteomics, which include protein bioinformatics, mass spectroscopy, protein labelling, imaging, and array based approaches, is one of the crucial factors expected to fuel up the market growth. Development of new biomarkers and various immunological techniques such as radioimmunoassay that can be used with carcinoembryonic antigen (CEA) for detection of various types of cancers, and thus also propel the market growth. For instance, the development of tumor markers, which is used in combination with CEA for detection of colorectal cancer. Favorable government initiatives to introduce new diagnostic tools/technologies is anticipated to boost the market growth. Moreover, rising demand for minimally invasive diagnostic procedures to avoid the various post procedure adverse effects impel the growth of this market.

Application Insights

This segment include key application, namely colorectal, ovarian, pancreatic, breast, thyroid and other cancer applications. In 2016, colorectal cancer dominated the market in terms of revenue share.

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Rising incidence of colorectal cancer and increase sensitivity to detect the antigen are the factors driving the growth of this segment. According to the American Cancer Society, in the U.S colorectal cancer is the third leading cause of death in women and second in men with nearly 95,520 new cases of colon cancer. Furthermore, increased consumption of alcohol, less physical activity, unhealthy diet, and rapidly changing lifestyle also contribute in the growth of colorectal cancer in the recent years.
Breast cancer is another segment experiencing significant growth owing to the factors such as rising female population above 50 years, advancements in biomarkers and increase in number of patients undertaking hormone replacement therapy (HRT), and breast augmentation & reconstruction surgery. Increasing government initiative coupled with rising consumer awareness for different treatment procedures is also driving the growth of the market. Moreover, other breast related diseases such as infections, lesions, and fibrocysts are also expected to contribute towards the growth in early diagnosis.

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Regional Insight

Regional segments of CEA market include North America, Europe, Asia Pacific, Latin America and MEA. In 2016, North America dominate the regional market pertaining to various key attributes such as increasing patient awareness, rising incidences of cancer, favorable reimbursement policies, and presence of advanced healthcare infrastructure. According to American Cancer Society in 2017, approximately 1,688,780 new cases of cancer were estimated in the U.S.

Asia Pacific region is expected to grow at lucrative rates during the forecast period owing to the factors such as increasing prevalence of cancer in emerging economies such as Brazil, Russia, India, and China, favorable government initiatives, and significant presence of local players will drive the growth of the market in this region. Asia Pacific has the highest mortality rate accompanied by North America. It has influenced the market in terms of cancer incidence rate affecting large population in 2012 at a changeable rate. Mexico and Brazil in Latin America will witness significant growth in the market owning to the factors such as increase alcohol consumption, excessive smoking, and changing lifestyles.

Competitive Insights

The global carcinoembryonic antigen market is consolidated in nature with extensive mergers and acquisitions. In 2017, Aviva Systems Corporation (ASB), a protein solutions and application provider is offering products for both research and diagnostic market acquired GenWay Biotech, Inc. Some of the key players in

this market include F. Hoffmann-La Roche Ltd; GenWay Biotech, Inc.; Abbott; Correlogic Systems, Inc.; Quest Diagnostics, Inc.; Lee BioSolutions; RayBiotech, Inc; Biocare Medical, LLC; and Abcam plc. Industry competition

level is expected to remain at moderately high level in the recent years Manufacturers are continuously introducing technologically advanced products that will raise the competition in the market.

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